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COMPOSITIONS AND METHODS FOR ACHIEVING HIGH LEVELS OF TRANSDUCTION IN HUMAN LIVER CELLS
COMPOSITIONS AND METHODS FOR ACHIEVING HIGH LEVELS OF TRANSDUCTION IN HUMAN LIVER CELLS
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机译:在人肝细胞中实现高水平转录的组合物和方法
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摘要
Use of a rAAV3B vector to deliver gene products to human hepatocytes is described. The rAAV3B vectors achieve high levels of transduction even in the presence of pre-existing immunity to AAV8 or AAVrh10. Compositions and treatment regimens are described. Also provided are rAAV engineered to facilitate purification and methods of purifying the AAV.
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