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METHOD FOR DETERMINING WHETHER CELLS OR CELL GROUPS ARE DERIVED FROM SAME PERSON, OR UNRELATED PERSONS, OR PARENT AND CHILD, OR PERSONS IN BLOOD RELATIONSHIP
METHOD FOR DETERMINING WHETHER CELLS OR CELL GROUPS ARE DERIVED FROM SAME PERSON, OR UNRELATED PERSONS, OR PARENT AND CHILD, OR PERSONS IN BLOOD RELATIONSHIP
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机译:确定是从同一个人,还是无关的人,还是父母和孩子,还是血统关系中的人确定细胞或细胞群的方法
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摘要
Provided is a method for determining whether cells or cell groups that have a possibility of being derived from a plurality of persons are derived from the same person, or unrelated persons, or a parent and a child, or persons in a blood relationship, the method including: a step of acquiring genotypic data for gene polymorphism sites of the cells or cell groups and weighting the data with a preset weight distribution, to acquire weighted genotypic data; and a step of using the weighted genotypic data to determine whether the cells or cell groups are derived from the same person, or unrelated persons, or a parent and a child, or persons in a blood relationship, in which the preset weight distribution is set by mapping of a measured apparent genotype and a true genotype with respect to the gene polymorphism sites, and the method being capable of determining, with high accuracy, whether the cells or cell groups are derived from the same person, or unrelated persons, or a parent and a child, or persons in a blood relationship, even in a case where errors due to DNA amplification and sequencing are large and errors frequently occur in thus obtained polymorphism information of genes in genetic analysis for a small amount of deoxyribonucleic acid (DNA).
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