Compositions which regulate the epithelial brush border Na⁺/H⁺ exchanger NHE3 and their methods of use in gastrointestinal disease

摘要

A synthetic peptide modeled on the IRCX binding area of NHE3, is a competitive inhibitor of the IRCX and both stimulates basal NHE3 activity and prevents elevated Ca²⁺ and cAMP inhibition of NHE3. Methods of its preparation and use in the prevention and/or treatment of gastrointestinal disease, such as diarrhea are provided.