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Method and device of plant dose pharmaceutical science production
Method and device of plant dose pharmaceutical science production
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机译:植物剂量药物科学生产的方法和装置
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摘要
Systems and Methods for producing a dosage regimen of coagulation factor VIII (cfviii) include collecting two samples of blood from a patient after an infusion of cfviii andDetermine the cfviii clearance on the basis of the two blood samples, and determine whether a patient has a half-life exceeding a Predetermined Threshold.Determining a Profile of the patient pharmacokinetic (PK) Model using a Bayesian pharmacokinetic Profiles of patients sampled with similar body weight and Age of the patient.The Model applies a First weighting Bayesian pharmacokinetic Profiles of patients sampled if the Half Life of the patient is higher than a Predetermined Threshold and applies.NDA weighting less than the first weighting, the Model Bayesian pharmacokinetic Profiles of patients sampled if the Half Life of the patient is less than the Predetermined Threshold.It determines a dosage regimen for the patient based on the PK Profile.
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