methods of treating breast cancer, prostate cancer, carcinoid cancer, ovarian cancer and lung cancer in patients.

摘要

Summary "Methods of treatment of breast cancer, prostate cancer, carcinoid cancer, ovarian cancer and lung cancer in patients" are provided cancer treatment methods comprising the amplification of the fgfr1 gene, overexpression of fgfr1, fgfr3 overexpression, fgfr3 amplification, fgf2 overexpression and / or fgf2 gene amplification. in some embodiments, the methods comprise administering a fibroblast growth factor receptor 1 (fgfr1) extracellular domain (ecd) and / or an fgfr1 ecd fusion molecule. in some embodiments, the methods comprise administering fgfr1 ecd and / or an fgfr1 ecd fusion molecule in combination with at least one additional therapeutic agent. In some embodiments, cancer treatment methods are provided which comprise administering fgfr1 ecd and / or an fgfr1 ecd fusion molecule in combination with at least one chemotherapeutic agent.