? gene, vector, host cell, virus-like particles, human papilloma virus vaccine, immunogenic composition, adjuvant, method for preparing a human papilloma vaccine, main capsid protein and hpv l1 protein?

摘要

The present invention provides genes encoding various hpv antigens of various serotypes. The gene of the present invention produces virus-like particles with enhanced immunological quality and quaternary structure. The present invention also provides a suitable host cell, preferably high copy number p.pastoris, of genes encoding various hpv antigens of various serotypes. The present invention additionally provides hpv antigen vaccine with an improved immunization schedule wherein the vaccine dosing regimen and antigen dose amount are reduced. The present invention also provides an improved human papillomavirus vaccine composition using yeast.