roneparstat and roneparstat for use, part kit and part kit for use, pharmaceutical composition, method for treating a mammal and method for inhibiting, treating, and / or preventing multiple myeloma, plasma cell myeloma, recurrent, refractory myeloma or relapsing into a subject

摘要

The present invention relates to roneparstat for use in a combination therapy for the treatment of multiple myeloma. In particular, it was unexpectedly found that the combined use of roneparstat with a proteasome inhibitor, in particular selected from bortezomib and carfilzomib or with melphalan, has improved efficacy in decreasing overall tumor burden, especially showing synergism with respect to administration of each active ingredient alone.