lipocalin mutein, nucleic acid molecule, expression vector, host cell, lipocalin mutein production method, methods of binding lag-3 in patients, stimulating immune reaction in patients, inducing t lymphocyte proliferation, interfere with human lag-3 binding and detection of the presence of lag-3, pharmaceutical composition, immunoconjugate, mutein use and analytical or diagnostic kit

摘要

The present invention provides human tear lipocalin muteins that specifically bind lag-3, which may be used in pharmaceutical applications, for example, as anticancer agents and / or immunity modulators for the treatment or prevention of human diseases such as cancer, infectious diseases and autoimmune diseases. The present invention further demonstrates that human lipocalin muteins can inhibit the binding of lag-3 to class ii mhc on class ii mhc overexpressing cells. The present invention also relates to methods of preparing lag-3-binding lipocalin muteins described herein, as well as compositions comprising such lipocalin muteins. The present invention further relates to nucleic acid molecules encoding such lipocalin muteins and methods of generating such lipocalin muteins and nucleic acid molecules. furthermore, the present application describes therapeutic and / or diagnostic uses of such lipocalin muteins, as well as compositions comprising one or more such lipocalin muteins.