composition, panel, method for determining the likelihood of preterm birth in a pregnant female and method of detecting ibp4 and shbg in a pregnant female?

摘要

The description provides a pair of isolated biomarkers selected from the group consisting of ibp4 / shbg, ibp4 / psg3, ibp4 / lyam1, ibp4 / igf2, clus / ibp3, clus / lyam1, inhbc / psg3, inhbc / igf2, psg2 / lyam1, psg2 / igf2, psg2 / lyam1, pedf / psg3, pedf / shyg, pedf / lyam1, cd14 / lyam1 and apoc3 / lyam1, wherein said pair of biomarkers exhibits a change in reversal value between females pregnant women at risk of preterm birth and pregnancy controls. Also provided is a method for determining the likelihood of premature birth in a pregnant female comprising measuring in a biological sample obtained from said pregnant female a reversal value for at least one pair of biomarkers selected from the group consisting of ibp4 / shbg, ibp4 / psg3, ibp4 / lyam1, ibp4 / igf2 clus / ibp3, clus / igf2, clus / lyam1, inhbc / igg2, psg2 / lyam1, psg2 / lyam1, pedf / psg3 shbg, pedf / lyam1, cd14 / lyam1 and apoc3 / lyam1 to determine the likelihood of premature birth in said pregnant female.