crystalline forms of posaconazole intermediate and process for the preparation of amorphous posaconazole

摘要

industrial production method of amorphous posaconazole. The present invention also relates to a method for the production of posaconazole by means of novel crystalline forms of posaconazole intermediate. more particularly, the present invention relates to novel crystal forms of posaconazole intermediate and methods for producing novel crystal forms of posaconazole intermediate represented by structural formula iii below, which is the major intermediate in the production of posaconazole. The present invention also enables the process in a container for the preparation of amorphous posaconazole using innovative crystalline forms of benzyl posaconazole.