use of a first polysaccharide derivative and a second polysaccharide derivative, first and second polysaccharide derivatives, a combination of a first hyaluronic acid derivative (ah) and a second hyaluronic acid derivative (ah), multicylinder syringe system, kit for locally forming a cross-linked polysaccharide hydrogel, method for locally forming a cross-linked hydrogel

摘要

The present invention relates to sterile locally cross-linkable polysaccharide compositions for augmenting, filling or replacing soft tissues in various cosmetic and therapeutic applications. The composition comprises a first polysaccharide derivative functionalized with a nucleophilic group and a second polysaccharide derivative functionalized with an electrophilic group. said nucleophilic and electrophilic functional groups spontaneously form covalent bonds locally after co-injection into a patient's body, resulting in the formation of a cross-linked hydrogel at the co-injection site.