USE OF BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF CHOLESTATIC LIVER DISEASE OR PRURITIS

摘要

Provided herein is the use of an Apical Sodium-dependent Bile Acid Transporter Inhibitor (ASBTI) selected from any of structural formulas provided below for treating a cholestatic liver disease or pruritis. Also provided are methods of treating a liver disease by administering to an individual in need thereof a therapeutically effective amount of a composition comprising ASBTI or a pharmaceutically acceptable salt or solvate thereof, wherein the liver disease is hepatitis A, hepatitis B, hepatitis C, non-alcoholic steatohepatitis (NASH), non-alcoholic fatty liver disease (NAFLD), hemochromatosis, Wilson's disease, ischemic hepatitis, liver inflammation, liver fibrosis, or a chronic liver disease.