MEF2A GENE EXPRESSION IN CORONARY ARTERY DISEASE PATIENTS

摘要

The present invention provides MEF2A gene expression in coronary artery disease (CAD) patients. Pathogenesis of CAD is based on the gene expression analysis. MEF2A directly regulates target genes in the process of muscle development. This gene product is a transcription factor. MEF2A protein is homodimer or heterodimer forms binds to A/T-rich Cis elements with conserved sequence in promoter, regulator, and enhancer of many genes, which are determining in evolution and development of skeletal, heart, and smooth muscle cells, especially endothelial cells