MULTIVALENT CD20 BINDING MOLECULES COMPRISING SHIGA TOXIN A SUBUNIT EFFECTOR REGIONS AND ENRICHED COMPOSITIONS THEREOF

摘要

The present invention provides multivalent CD20 binding molecules and compositions thereof such as enriched compositions comprising large proportions of multivalent CD20 binding molecule relative to monovalent CD20 binding molecule. Certain multivalent CD20 binding molecules of the present invention comprise 1) two or more CD20 binding regions and 2) one or more Shiga toxin effector polypeptide regions derived from an A Subunit of a member of the Shiga toxin family. Certain multivalent CD20 binding molecules of the present invention and compositions thereof have uses for selective killing specific cell types and as therapeutics for the treatment of a variety of diseases including cancers tumors and immune disorders. Certain multivalent CD20 binding molecules of the present invention and compositions thereof have uses for delivering agents into CD20 expressing cells including for the intracellular labeling of CD20 expressing cells collecting diagnostic information and monitoring the treatment of variety diseases such as cancers tumors and immune disorders which involve CD20 expressing cells.