ENGINEERED KETOREDUCTASE ENZYME DERIVED FROM WILD-TYPE KETOREDUCTASE ENZYME OF SACCHAROMYCES CEREVISIAE

摘要

pThe present disclosure provides ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, method of using the engineered ketoreductase enzymes to synthesize a variety of chirally pure compounds, and the chirally pure compounds prepared therewith/p [WO2008042876A2]