Monoclonal antibodies against tissue factor pathway inhibitor (tfp1)

摘要

Disclosed is a monoclonal antibody, or antigen binding fragment thereof which binds to an epitope in human tissue factor pathway inhibitor (TFPI), which epitope is characterised by specific binding by an antibody (4B7) comprising an LCDR1 having an amino acid sequence of SEQ ID NO: 212 LCDR2 having an amino acid sequence of SEQ ID NO: 255, LCDR3 having an amino acid sequence of SEQ ID NO: 298, an HCDR1 having an amino acid sequence of SEQ ID NO: 341, an HCDR2 having an amino acid sequence of SEQ ID NO: 384 and an HCDR3 having an amino acid sequence of SEQ ID NO: 427, wherein the antibody or antigen binding fragment shows cross-reactivity to murine TFPI and binds kunitz domain 1 and domain 2.