The pre production period of a new pyridine derivative 4,5-b pyridine and the synthesis process of the pharmaceutical containing pyridine

摘要

It refers to formula compound (I),Their dwarfs, their cholesterol and their addictive salts are all equally pharmacologically acceptable, where R1 is a cyanogen group, a halogenated atom, and a tar group (C1-C6),Among other things, R2 is a hydrogen compound, a group of asphalt (C1-C6) linear or separated daughters; R3 is a hydrogen atom, halogenation, etc.; R4 and R5 are independent hydrogen atoms or halogenated atoms; these compounds are derivatives of pyridan [4.5-b] pyridyl and inhibitors of dyrk1 / CLK1. The preferred compound is 4 - [2-methyl-3 - (3-phenyl-cyclodibutyl) - 3h-pyridan [4,5-b] pyridine-5-il] pyridine-2,6-diamond, etc. It also refers to the preparation process, pharmacological composition and use in the treatment of cancer, neurodegenerative disorder or metabolic disorder.