III. protection of three elements and / or three elements

摘要

Three kinds of binding proteins with (or) trivalent are provided, which are composed of four polypeptide chains, forming three antigen binding points, specifically binding one or more albumin, The polypeptides of the first pair of combinatorial proteins have dual variable domains and cross directions, while the polypeptides of the second pair of combinatorial proteins have a simple variable domain. The description also provides a method for making three or trivalent binding proteins and the use of such binding proteins.