Combination therapy of cancer with anti-thygline antibodies and anti-VEGF agents

摘要

A method for inhibiting the outbreak of new vessels induced by VEGF by contacting cells in vitro with a composition comprising a chimeric antndoglin antibody and a composition comprising an antagonistic anti-VEGF antibody; said chimeric antndoglin antibody comprises a light chain variable region (VL) having an amino acid sequence that is exposed as sec. with no. of ident .: 1; a light chain constant region (CL) having an amino acid sequence that is exposed as sec. with no. of ident .: 2; a heavy chain variable region (VH) that has an amino acid sequence that is exposed as sec. with no. of ident .: 3; and a constant region (Fc) that has an amino acid sequence that is exposed as sec. with no. Ident .: 4.