New procedure for the synthesis of 7-methoxynaphthalen-1-carbaldehyde and use in the synthesis of agomelatine

摘要

Industrial synthesis procedure of the compound of formula (I): ** (See formula) ** characterized in that 7-methoxynaphthalen-2-ol of formula (III) is subjected to reaction: ** (See formula) ** on which a formyl group is introduced at position 1 to obtain the compound of formula (IV): ** (See formula) ** compound of formula (IV) that is subjected to a sulfonylation reaction to obtain the compound of formula (V) : ** (See formula) ** where R represents a group -CH3, - (CH2) 2-CH3, -CF3 or toluyl; compound of formula (V) that is subjected to a deoxygenation reaction in the presence of a transition metal and a reducing agent to obtain the compound of formula (I), which is isolated in the form of a solid.