A METHOD OF REDUCING SERUM PROINSULIN LEVELS IN TYPE 2 DIABETICS

摘要

Methods are provided for reducing serum proinsulin levels, lessening post-prandial pancreatic stress, and reducing risk factors for atherosclerosis insubjects with diabetes mellitus, type 2. The method includes administration ofinsulin in a manner that mimics the meal-related first phase insulin response,using a dose sufficient to reduce serum levels of proinsulin. In someembodiments of the method insulin administration is commenced early in thecourse of the disease. Mimicking first phase kinetics, peak serum insulinlevels can be reached within about 18 minutes of administration. Inincreasingly preferred embodiments peak serum insulin levels can be reachedwithin about 15, 12, or 10 minutes of administration. Serum insulin levelsreturn to baseline within about two hours of administration.