HUMAN ANTI-TETANUS MONOCLONAL ANTIBODIES NEUTRALISING INFECTION BY C. TETANI, METHOD FOR OBTAINING SAID MONOCLONAL ANTIBODIES AND USE THEREOF IN IMMUNOTHERAPY IN THE CASE OF ACCIDENTS WITH POSSIBLE INFECTION BY TETANUS BACILLUS

摘要

The present invention relates to human anti-tetanus monoclonal antibodies against C. tetani infection, obtained by genetic engineering techniques using the information about the gene sequence obtained from B lymphocytes in the peripheral blood of persons vaccinated with tetanus toxoid. The genetic information is inserted into vectors used for transfecting mammal cells, with the aim of generating cell lines producing anti-tetanus monoclonal antibodies. Another aspect of the present invention relates to immunological compositions containing said monoclonal antibody, and to the uses thereof for the treatment and/or immunotherapy of tetanus infection.