A method of identifying and guiding cortical stimulation sites for the application of a focal-neuromodulation technique

摘要

The invention relates to a method for identifying at least one cortical stimulation site in a subject for the application as a target that can be used for treatment of a psychiatric or neurological disorder related to a deep brain region of the ventromedial prefrontal cortex including the subgenual and rostral anterior cingulate by using a first focal-neuromodulation technique, said method comprising: -applying pulsesof a second a focal-neuromodulation technique to different cortical areas of said subject; -simultaneously with the application of said pulses at a said cortical area measuring a psychophysiological signal representative of a heart rate of said subject for said cortical area, and -when observing a systematic change in said psychophysiological signal, identifying a corresponding cortical area as said at least one cortical stimulation site that is functionally connected to said deep brain region of the ventromedial prefrontal cortex including the subgenual and rostral anterior cingulate for presenting said target for said treatment.