METHOD FOR ESTABLISHING QUANTITATIVE REFERENCE RANGE FOR HEALTHY PERSON URINARY PROTEOME AND ACQUIRING DISEASE-RELATED URINARY PROTEIN MARKER

摘要

A method for establishing a quantitative reference range for the urinary proteome of a healthy person and for acquiring a disease-related urinary protein marker: acquiring a quantitative reference range for the urinary proteome of a healthy person on the basis of an established urinary proteome data set of the healthy person, using a hypergeometric distribution inspection method in a urinary proteome data set of a patient of a certain disease to screen for an outlier protein to serve as a urinary protein marker related to the disease, and establishing a tumor-related outlier urinary protein library with a tumor as an example. The method eliminates interferences from physiological fluctuations and differential proteins between individuals in a screening process for a urinary protein biomarker.