PREDICTING, DIAGNOSING, AND TREATING NAUSEA AND VOMITING OF PREGNANCY

摘要

Assays for identifying patients at risk for nausea and vomiting in pregnancy (NVP) and hyperemesis gravidarum (HG), as well as methods for diagnosis and/or treatment of HG and NVP. Described herein is a method of analyzing genetic expression in a sample obtained from a subject. The method comprises obtaining a sample from the subject; and measuring the level of expression product of at least one of the HG outlook genes. Expression products to be detected include proteins and nucleic acid sequences. Antibodies and/or probes can be used to detect HG outlook gene expression products, such as GDF15 and IGFBP7, in samples, including serum, urine, and blood, obtained from patients. Treatment for NVP and/or HG can be selected on the basis of the assay.