- Expression validation of protein expressed uniquely by scrapie prion protein and use for development of biomarker for the diagnosis of Creutzfeldt-Jakob disease

摘要

The present invention relates to the verification of specific protein expression in brain tissue of transformed prion-infected mice. Identification of information and biological pathways of whole proteins identified in transformed prion-infected brain tissues can be used to identify mechanisms of prion in vivo and to identify additional candidate diagnostic indicators It is worth using as a selectable database. Blood fluid, such as blood, circulates in almost all tissues of the body and is secreted by specific tissues or contains proteins from dead cells of the tissues, reflecting the state of the organ, and can also be easily collected for non-invasive ) Can be diagnosed. The present invention has confirmed the expression of ACSBG1 protein by selecting a candidate diagnostic marker which has not been reported in prion disease in a biological pathway analyzed from infected mouse brain tissue protein information. The ACSBG1 protein expression is increased in the transformed prion-infected mouse compared to the normal group. Thus, the present invention is useful as a method of screening a candidate for Crotszfeldt-Jakob disease diagnostic kit or biochip by using the ACSBG1 protein expression change by screening Can be used.