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Biomarker for non-invasive diagnosis of glomerular diseases and method for detecting the same

机译:用于肾小球疾病的非侵入性诊断的生物标志物及其检测方法

摘要

The present invention relates to a biomarker capable of diagnosing a glomerular disease by a non-invasive method, comprising a protein biomarker capable of diagnosing a chronic renal disease from a bio-fluid of a glomerular disease patient and a method for detecting the biomarker . Body fluids are biopsied to diagnose glomerular disease, and proteins are concentrated and used. Protein is decomposed into peptides through enzymatic reaction and analyzed by mass spectrometer (LC-MS / MS) to identify proteins. In addition, the protein biomarker of the present invention can be used as a diagnostic kit capable of early diagnosis of glomerular disease. It is expected that the diagnosis and treatment of glomerular diseases will enable early diagnosis and treatment of end - stage renal disease, thereby contributing to the public health.
机译:本发明涉及能够通过非侵入性方法诊断肾小球疾病的生物标志物,其包括能够从肾小球疾病患者的生物流体诊断慢性肾脏疾病的蛋白质生物标志物和检测该生物标志物的方法。对体液进行活检以诊断肾小球疾病,然后浓缩并使用蛋白质。蛋白质通过酶促反应分解为肽,并通过质谱仪(LC-MS / MS)进行分析以鉴定蛋白质。另外,本发明的蛋白质生物标志物可以用作能够早期诊断肾小球疾病的诊断试剂盒。预期肾小球疾病的诊断和治疗将使早期诊断和治疗晚期肾病成为可能,从而有助于公众健康。

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