METHOD OF SYNTHESIZING -SUBSTITUTED GAMMA NITRO DI-THIOESTER COMPOUNDS -SUBSTITUTED GAMMA NITRO DI-THIOESTERS COMPOUNDS SYNTHESIZED BY THE METHOD GAMMA AMINO ACID COMPOUND DERIVATED FROM THE -SUBSTITUTED GAMMA NITRO DI-THIOESTERS COMPOUNDS AND METHOD OF SYNTHESIZING GAMMA AMINO BUTYRIC ACID FROM THE -SUBSTITUTED GAMMA NITRO DI-THIOESTER COMPOUNDS OR THE GAMMA AMINO ACID COMPOUND

摘要

Disclosed is a method of synthesizing a γ-nitro dithioester compound. The γ-nitro dithioester compound can be synthesized by Michael reaction of a dithiomalonate compound and a β,β-disubstituted nitroalkene compound having a substituent containing two carbons in a beta position under the presence of a catalyst including a base in water or an aqueous inorganic salt solution. The synthesized γ-nitro dithioester compound has a substituent containing two carbons in the beta position. The γ-nitro dithioester compound having a substituent containing two carbons in the beta position can be synthesized in a racemic or high mirror image stereoselectivity by forming a new carbon-carbon bond that has not conventionally been possible to form even without using chiral auxiliaries or expensive peptide catalysts as much as the number of equivalents.