Substituted tricyclic 1,4-benzodiazepinone derivatives as allosteric modulators of the Group II metabotropic glutamate receptors

摘要

The present invention provides novel tricyclic 1,4-benzodiazepinone derivatives of formula I and pharmaceutical compositions containing them. Moreover, the compounds of formula I and pharmaceutical compositions containing them can be used for the treatment of conditions which may be influenced by altered glutamate activity signaling and / or function-related conditions and / or glutamate concentrations or signaling in the mammal, and / It is provided for use in prevention. The tricyclic 1,4-benzodiazepinone derivatives of formula (I) above may act as modulators of glutamate-sensitive nervous system receptors, particularly as modulators of metabotropic glutamate receptors (mGluRs), which cause acute and chronic neurological And / or for the treatment and / or prevention of psychiatric disorders. The present invention further provides a tricyclic 1,4-benzodiazepinone derivative of formula I, which is a modulator of metabotropic glutamate receptor (mGluR), particularly a positive allosteric modulator of mGluR, more particularly a positive allosteric modulator of mGluR3 do.Formula I ;