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3 mTOR KINASE INHIBITORS FOR ONCOLOGY INDICATIONS AND DISEASES ASSOCIATED WITH THE mTOR/PI3K/Akt PATHWAY

机译：3种mTOR激酶抑制剂，用于与mTOR / PI3K / Akt通路相关的肿瘤适应症和疾病

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摘要

The present invention relates to a method of treating a cancer, an inflammatory disease, an immunological disease, a neurodegenerative disease, a neurodegenerative disease, a neurodegenerative disease, a neurodegenerative disease, a neurodegenerative disease, neurodegenerative disease, diabetes, obesity, neurological disorder, senile dementia, or cardiovascular disease, comprising:(I) or (II) Wherein R ¹ -R ⁴ are as defined in the present invention.

机译：本发明涉及治疗癌症，炎性疾病，免疫疾病，神经退行性疾病，神经退行性疾病，神经退行性疾病，神经退行性疾病，神经退行性疾病，神经退行性疾病，糖尿病，肥胖症，神经系统疾病，老年性痴呆或心血管疾病，包括：（I）或（ II ）其中R ^{1 -R ^{4 如本发明中所定义。}} 展开▼

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公开/公告号KR101815604B1

专利类型

公开/公告日2018-01-05

原文格式PDF

申请/专利权人 시그날 파마소티칼 엘엘씨;
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申请/专利号KR20117012069

发明设计人 엘스너 얀;하리스 로이 엘.;리 브랜든;몰텐센 드보라;패커드 개릭;파파 패트릭;페린-닌코빅 소피;리그스 제니퍼;산카 사비타;사피엔자 존;쉐블린 그라지엘라;테라니 리다;수 웨이밍;자오 징징;파니스 제이슨;마다카무틸 로우이;펄츠 킴벌리;날라 라마 케이.;
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申请日2009-10-27

分类号C07D487/04;A61K31/4985;C07D498/14;

国家 KR

入库时间 2022-08-21 12:38:42

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1. 用于与mTOR/PI3K/AKT/途径相关的肿瘤适应症和疾病的mTOR激酶抑制剂 [P] . 中国专利： CN104725384B . 2019.09.06

2. 用于与mTOR/PI3K/AKT/途径相关的肿瘤适应症和疾病的mTOR激酶抑制剂 [P] . 中国专利： CN104744475B . 2018.01.12

3. PYRAZINO2,3-bPYRAZINE mTOR KINASE INHIBITORS FOR ONCOLOGY INDICATIONS AND DISEASES ASSOCIATED WITH THE mTOR/PI3K/AKT PATHWAY [P] . 美国专利： US2020262840A1 . 2020-08-20

机译：吡嗪并[2,3-b]吡嗪mTOR激酶抑制剂用于与mTOR / PI3K / AKT途径相关的肿瘤适应症和疾病

4. PYRAZINO2,3-bPYRAZINE mTOR KINASE INHIBITORS FOR ONCOLOGY INDICATIONS AND DISEASES ASSOCIATED WITH THE mTOR/PI3K/AKT PATHWAY [P] . 美国专利： US2019077806A1 . 2019-03-14

机译：吡嗪并[2,3-b]吡嗪mTOR激酶抑制剂用于与mTOR / PI3K / AKT途径相关的肿瘤适应症和疾病

5. 3 mTOR KINASE INHIBITORS FOR ONCOLOGY INDICATIONS AND DISEASES ASSOCIATED WITH THE mTOR/PI3K/Akt PATHWAY [P] . 韩国专利： KR101896855B1 . 2018-09-07

机译： 3种mTOR激酶抑制剂，用于与mTOR / PI3K / Akt通路相关的肿瘤适应症和疾病

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3. Qishen decoction suppresses liver fibrosis by downregulating PI3K/Akt/mTOR signal pathway [J] . Shuo-Xi Li, Bing-Yu Wang, Lei Yang, 海南医科大学学报（英文版） . 2020,第012期

4. Danusertib, a potent pan-Aurora kinase and ABL kinase inhibitor, induces cell cycle arrest and programmed cell death and inhibits epithelial to mesenchymal transition involving the PI3K/Akt/mTOR-mediated signaling pathway in?human gastric cancer AGS [J] . Chun-Xiu Yuan, Zhi-Wei Zhou, Yin-Xue Yang, Drug Design, Development and Therapy . 2015,第4期

5. RES-529: a PI3K/AKT/mTOR pathway inhibitor that dissociates the mTORC1 and mTORC2 complexes [J] . Weinberg Mark A. Anti-cancer drugs . 2016,第6期

6. Dual PI3K/mTOR inhibitor BEZ235 as a promising therapeutic strategy against paclitaxel-resistant gastric cancer via targeting PI3K/Akt/mTOR pathway [J] . Dongshao Chen, Xiaoting Lin, Cheng Zhang, Cell death & disease. . 2018,第2期

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