Method For Separating And Washing Of Microparticles Via A Stratified Coflow Of Non-Newtonian And Newtonian Fluids

摘要

The present invention relates to a method for separating and cleaning fine particles using a co-current laminar flow of a viscoelastic fluid and a viscous fluid, wherein a viscous fluid, together with the viscoelastic fluid, Of the fine particles contained in the viscous fluid can be more easily moved to the desired target among the fine particles contained in the viscoelastic fluid without using a separate apparatus and attraction through the change of the focusing position with respect to the target particle in the flow of the parallel particles formed in the fluid channel, Native biofluids, which are mostly used in research and clinical applications, are mostly viscoelastic fluids, which can be used to separate particles only into viscous fluids or to move targeted particles contained in viscoelastic fluids to the viscous fluid for cleaning. Change the solution to hold the cells / particles It is possible to separate and clean the target particles without dilution of the target material, and if the relaxation time of the natural biofluids as the viscoelastic fluid is insufficient, an additional artificial polymer can be added , The throughput per hour is very high compared with other methods and it shows high efficient operation efficiency in a wide range of flow rate. Therefore, it is possible to perform a highly efficient separation and cleaning operation by merely pumping the syringe without the need of a sophisticated pumping device Respectively.;