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1 1 INHIBITOR OF CASEIN KINASE 1 AND CASEIN KINASE 1
1 1 INHIBITOR OF CASEIN KINASE 1 AND CASEIN KINASE 1
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机译:1 1酪蛋白激酶1和酪蛋白激酶1的抑制剂
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摘要
A novel oxazolone derivative having an inhibitory activity against casein kinase 1? And casein kinase 1 ?. In addition, by inhibiting casein kinase 1? And casein kinase 1 ?, the inhibitor provides a medicament useful for the treatment and / or prevention of diseases wherein the activation mechanism of casein kinase 1? Or casein kinase 1? Is related to the condition. In particular, the inhibitors provide medicaments useful for the treatment of biorhythmic cycle disorders (including sleep disorders), central nervous system disorders, and cancers. A casein kinase 1? And casein kinase 1? Inhibitor comprising an oxazolone derivative represented by the general formula (1), a salt thereof, a solvate thereof, or a hydrate thereof as an active ingredient. [In the formula (1), X represents a halogen atom (which may be a fluorine atom, a chlorine atom, a bromine atom or an iodine atom)
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