Pharmaceutical composition for preventing and treating for gallstone or cholecystitis containing with Carfilzomib as active ingredient

摘要

The present invention relates to a pharmaceutical composition for the prevention or treatment of gallstone disease containing carfilzomib or a pharmaceutically acceptable salt thereof as an active ingredient. In the present invention, carfilzomib inhibits gallstone formation in a high cholesterol diet-induced rats, reduces gene expression of SREBP-2 and HMGCR involved in cholesterol synthesis, and inhibits CYP7A1, CYP7B1 , CYP27A1, and CYP8B1, and cholesterol secretion of cholesterol, as well as ABCG5 and ABCG8 gene expression. Furthermore, it was confirmed that expression of SHP, FXR and PXR was inhibited and protein phosphorylation of JNK and ERK was increased. The above-mentioned calfirazomib inhibits the production of cholesterol and inhibits the secretion of bile into bile, and thus a composition containing calfirazomib as an active ingredient can be usefully used for prevention or treatment of gallstone disease.