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APPLICATION OF SMALL MOLECULES TO INCREASE EXPRESSION OF MAFA IN PANCREATIC ENDOCRINE CELLS
APPLICATION OF SMALL MOLECULES TO INCREASE EXPRESSION OF MAFA IN PANCREATIC ENDOCRINE CELLS
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机译:应用小分子提高胰腺内分泌细胞中MAFA的表达
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摘要
The present invention provides methods, cell cultures and differentiation media to promote differentiation of pluripotent stem cells to pancreatic endocrine cells of a mature phenotype. The resulting pancreatic endocrine cells express single hormonal insulin, PDX1, NKX6.1, and MAFA. In one or more differentiation stages, culturing may be carried out in a culture vessel at the air-liquid interface.
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