METHOD AND TEST SYSTEM FOR DETERMINATION OF SHARE OF FETAL DNA IN PLASMA OF PREGNANT WOMAN USING HIGH-PRODUCTIVE SEQUENCING METHODS

摘要

FIELD: medicine.;SUBSTANCE: invention is intended to determine the share of fetal DNA in the plasma of a pregnant woman using high-productive sequencing methods. 53 single nucleotide polymorphisms (SNP) located on 1-12 chromosomes with a heterozygote frequency of 40-50%, and specific primers to them are used. The share of fetal DNA is determined as a median of the fetal DNA share value for all informative SNPs.;EFFECT: effective determination of the share of fetal DNA in the blood plasma of a pregnant woman, regardless of the sex of the fetus.;4 tbl, 2 ex