METHOD FOR DETECTION OF TUMOUR GROWTH Pdcd4 SUPPRESSOR SUPPRESSION INHIBITORS IN TUMOUR CELLS AND pLucPdcd4 GENETIC CONSTRUCT FOR ITS IMPLEMENTATION

摘要

FIELD: medicine.;SUBSTANCE: method for detection of inhibitors of suppression of Pdcd4 tumour growth suppressor in tumour cells and pLucPdcd4 genetic construct, which is a plasmid encoding a reporter protein that is a firefly luciferase chimera with a human Pdcd4 protein, is proposed.;EFFECT: group of inventions allows to identify substances with known and presumed ability to inhibit Pdcd4 suppression in tumour cells as inhibitors of suppression of Pdcd4 tumour growth suppressor.;4 cl, 4 dwg, 6 ex