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Use of RiV preparations for the treatment of cerebral infarction

机译:RiV制剂在治疗脑梗死中的用途

摘要

Use of BK-RiV preparations containing RiV particles with a size of 30 to 70 nm for the preparation of medicaments for the treatment of cerebral infarction, wherein the production of BK-RiV preparations comprises the following steps: - Cultivation of primary, diploid or unlimited - stressing the cells, preferably by starvation stress due to the use of medium without serum, resulting in the 30-70 nm RiV particles, - cell disruption, - separation of larger cell debris, - enrichment of the RiV particles in the resuspended sediment by ultracentrifugation and short-term solvent treatment or by ultrafiltration or by affinity chromatography, - recovery of the aqueous phase containing the RiV particles after low-speed centrifugation.
机译:包含大小为30至70 nm的RiV颗粒的BK-RiV制剂在制备用于治疗脑梗死的药物中的用途,其中BK-RiV制剂的生产包括以下步骤:-培养原代,二倍体或无限量-对细胞施加压力,最好是由于使用不含血清的培养基而因饥饿而产生压力,从而产生30-70 nm RiV颗粒;-细胞破裂;-分离较大的细胞碎片;-通过重新悬浮沉淀物富集RiV颗粒超速离心和短期溶剂处理,或通过超滤或通过亲和色谱法,-低速离心后回收含有RiV颗粒的水相。

著录项

  • 公开/公告号DE102007004991B4

    专利类型

  • 公开/公告日2018-08-30

    原文格式PDF

  • 申请/专利权人 VARICULA BIOTEC GMBH;

    申请/专利号DE20071004991

  • 发明设计人 GLEICH PATENTINHABER;

    申请日2007-02-01

  • 分类号A61K31/7105;A61K38;A61P25;A61K35/12;A61P9/10;

  • 国家 DE

  • 入库时间 2022-08-21 12:35:08

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