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USES OF EPITHELIAL-TO-MESENCHYMAL INHIBITORS IN GENERATING PACEMAKER CELLS
USES OF EPITHELIAL-TO-MESENCHYMAL INHIBITORS IN GENERATING PACEMAKER CELLS
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机译:上皮间充质细胞抑制剂在生成细胞中的应用
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摘要
This disclosure relates to methods of generating pacemaker cells for use in therapeutic strategies that address a heart that beats abnormally. In certain embodiments, one mixes cells with an epithelial-to-mesenchymal transformation inhibitor in combination with a nucleic acid encoding a transcription factor such as a vector that encodes a transcription factor such as Tbx18 in operable combination with a eukaryotic promoter to produce pacemaker cells that are then transplanted into the heart.
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