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PREVENTION AND TREATMENT OF FIBROBLAST GROWTH FACTOR 23 (FGF23)-ASSOCIATED DISORDERS INCLUDING CHRONIC KIDNEY DISEASE (CKD)
PREVENTION AND TREATMENT OF FIBROBLAST GROWTH FACTOR 23 (FGF23)-ASSOCIATED DISORDERS INCLUDING CHRONIC KIDNEY DISEASE (CKD)
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机译:预防和治疗成纤维细胞生长因子23(FGF23)相关的疾病,包括慢性肾脏病(CKD)
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摘要
The invention discloses WNK signalling inhibitors, in particular closantel, for use in the prevention and treatment of disorders caused and/or characterized by elevated levels of serum fibroblast growth factor (FGF23), especially chronic kidney disease (CKD). The invention also provides pharmaceutical compositions comprising one/or more WNK signalling inhibitors and methods for use said pharmaceutical compositions in the treatment of subjects diagnosed with FGF23-associated disorders, wherein subjects may be humans and/or companion animals, e.g. dogs and cats.
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