TOLEROGENIC SYNTHETIC NANOCARRIERS TO REDUCE OR PREVENT ANAPHYLACTIC RESPONSE TO NON-ALLERGENIC ANTIGENS

摘要

To provide methods usable for reducing or preventing anaphylaxis by administration of non-allergenic antigens such as non-allergenic therapeutic macromolecules.SOLUTION: Disclosed herein is a method for reducing or preventing anaphylactic response to a non-allergenic antigen, comprising: providing a non-allergenic antigen which is not attached to a synthetic nanocarrier; providing a composition comprising a synthetic nanocarrier attached to an immunosuppressant; and administering the composition with the non-allergenic antigen to a subject.SELECTED DRAWING: None