COMPOSITIONS FOR PROMOTING DELAYED MELATONIN SECRETION ONSET TIME, COMPOSITIONS FOR IMPROVING EARLY WAKENING AND COMPOSITIONS FOR IMPROVING ADVANCED CIRCADIAN RHYTHM PHASE

摘要

To provide novel compositions to safely and simply improve, prevent, and/or treat circadian rhythm disturbance with safe daily intake.SOLUTION: The invention relates to a composition for promoting delay of melatonin secretion onset time comprising ornithine or pharmaceutically acceptable salt or solvate thereof, a composition for improving early wakening comprising ornithine or pharmaceutically acceptable salt or solvate thereof, and a composition for improving advanced circadian rhythm phase comprising ornithine or pharmaceutically acceptable salt or solvate thereof.SELECTED DRAWING: Figure 3