Highly selective sigma receptor and radioligands as probes in pathophysiological studies of nociceptive processing and memory impairment and cognitive abnormalities

摘要

Method for quantifying localized role S1R in nociceptive processing, a method of providing an indication for providing analgesia therapy uses S1R selective ligands as biomarkers for memory impairment and cognitive abnormality pathophysiological studies method, or a method of detecting an increase in S1R density at the site of nerve injury resulting from neuropathic pain is provided, the method comprising the general formula III 'or IV' at least one SR1 selective compounds or probes radioligand having comprising the step of using.