Chemical conjugates of Evans blue derivatives and their use as radiotherapeutic and imaging agents

摘要

The present invention relates to compounds of formula I or formula III, or pharmaceutically acceptable esters, amides, solvates or salts thereof, or salts of such esters or amides, or solvates of such esters, amides or salts . In the formula, the definitions of R1 to R13 and L1 to L4 are as described in the specification, and in the formula, R14 is a peptide. A compound of Formula I is covalently linked to a peptide via a linker to prepare a compound of Formula III, thereby extending the half life of the therapeutic compound. The invention also relates to pharmaceutical compositions of the disclosed compounds, as well as their use in the diagnosis or treatment of diseases.