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Methods for identifying forgiving subjects

机译:识别宽恕对象的方法

摘要

The present invention is a method for discriminating between an immunotolerant (TOL) subject after transplantation and a non-tolerant (STA) subject after transplantation, i) of six genes in a biological sample obtained from said subject. Establishing a compound tolerance score (cSoT) according to expression level and two clinical parameters, wherein the six genes are ID3, AKR1C3, CD40, CTLA4, TCL1A and MZB1, wherein the cSoT is represented by the following formula: Ii) conclude that the subject is a TOL if cSoT is higher than the predetermined reference value; ii) compare this cSoT with a predetermined reference value; Or a method comprising concluding that the subject is a STA if the cSoT is lower than a predetermined reference value. [Selection figure] None
机译:本发明是一种用于区分移植后的免疫耐受(TOL)受试者和移植后的非耐受(STA)受试者的方法,i)从所述受试者获得的生物样品中的六个基因。根据表达水平和两个临床参数建立复合耐受评分(cSoT),其中六个基因是ID3,AKR1C3,CD40,CTLA4,TCL1A和MZB1,其中cSoT由下式表示:Ii)得出结论:受试者如果cSoT高于预定参考值,则为TOL; ii)比较该cSoT与预定参考值;或一种方法,其包括如果所述cSoT低于预定参考值则认为所述受试者是STA。 [选择图]无

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