Methods for controlled proliferation of vestibular stem cells / generation of inner ear hair cells using WNT and TGF-beta inhibition

摘要

Wnt agonist, GSK3α inhibitor, or GSK3β inhibitor together with a TGF-β inhibitor, including inducing stem cells / progenitor cells of supporting cells to proliferate while maintaining the ability to differentiate into hair cells in daughter cells Used in combination, compositions and methods for inducing stem / progenitor self-renewal of supportive cells are provided.