Spinal ligament ossification model non-human animal, diabetes model non-human animal, spinal ligament ossification model cell, diabetes model cell, screening method, detection method of vertebral ligament ossification lesion cell, spinal ligament ossification diagnosis kit , And therapeutic agent for ossification of spinal ligament

摘要

PROBLEM TO BE SOLVED: To provide an ossification of spine ligament model non-human animal that becomes a model of ossification of spine ligament.SOLUTION: (1) An ossification of spine ligament model non-human animal is characterized in that a function of CXCL7 genes is lost or suppressed, or an expression of miRNA-340 is enhanced. (2) The ossification of spine ligament model non-human animal is characterized in that the loss or suppression of the function of the CXCL7 genes is caused by the deficiency, insertion, addition or replacement of a part or the whole of the CXCL7 genes or the expression control region. (3) The ossification of spine ligament model non-human animal is characterized in that the enhancement of the expression of the miRNA-340 is caused by the introduction of the miRNA-340.SELECTED DRAWING: None