Cell-based treatment and drug discovery in Hirschsprung's disease enabled by pluripotent stem cells derived from human enteric neural crest lineage

摘要

The subject matter of the present disclosure provides in vitro methods for inducing stem cell differentiation into enteric neural crest lineage cells, and enteric neural crest lineage cells by such methods. The subject matter of the present disclosure is also for preventing and / or treating enteric nervous system disorders (eg, Hirschsprung's disease) and for preventing and / or treating enteric nervous system disorders (eg, Hirschsprung's disease). The use of such enteric neural crest lineage cells for screening suitable compounds is provided.