Acute severe hepatitis model: method for producing non human animal, screening method for therapeutic agent for fulminant hepatitis and therapy for fulminant hepatitis B

摘要

PROBLEM TO BE SOLVED: To provide a manufacture method of an acute severe hepatitis model nonhuman animal capable of advancing an abrupt damage of a human hepatocyte, the acute severe hepatitis model nonhuman animal, a screening method for a fulminant hepatitis curative medicine, and the fulminant hepatitis curative medicine.SOLUTION: A manufacture method of an acute severe hepatitis model nonhuman animal comprises: a first administration step of administrating an immunity administration to a super-immune deficient non-human animal, in which a human hepatocyte is applied to a liver; and a second administration step of administrating a human being peripheral blood mononuclear ball to the super-immune deficient non-human animal, to which the immunity administration was administrated.SELECTED DRAWING: Figure 1