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Echogenic vehicle for clinical delivery of plasminogen activator and other fibrin-binding therapeutics to thrombi
Echogenic vehicle for clinical delivery of plasminogen activator and other fibrin-binding therapeutics to thrombi
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机译:用于将血纤蛋白溶酶原激活剂和其他血纤蛋白结合治疗剂临床交付给血栓的Echogenic载体
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摘要
We disclose a composition comprising an echogenic liposome (ELIP) having an exterior surface, an interior surface, and at least one bilayer comprising at least one lipid selected from the group consisting of saturated phospholipids, unsaturated phospholipids, mixed phospholipids, and cholesterol, and a thrombolytic compound trapped by the ELIP. We also disclose a method of treating a medical condition in a patient characterized by a thrombus in the patient's vasculature, comprising administering to the patient the composition in an amount effective to reduce the size of the thrombus.
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