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Cell-permeable peptide system for treating diseases caused by glutamate excitotoxicity

机译：用于治疗由谷氨酸兴奋性毒性引起的疾病的细胞渗透性肽系统

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摘要

Peptide system including at least one peptide blocking the presynaptic release of glutamate. The peptide has the sequence SEQ ID NO 5: GRKKRRQRRRPPIEQSIEQEEGLNRS and/or sequence SEQ ID NO 8: GRKKRRQRRRPPMSEYNATQSDYRER for use in treating pathologies associated with glutamate excitotoxicity.

机译：肽系统，其包含至少一种阻断谷氨酸的突触前释放的肽。该肽具有序列SEQ ID NO： 5 ：GRKKRRQRRRPPIEQSIEQEEGLNRS和/或序列SEQ ID NO： 8 ：GRKKRRQRRRPPMSEYNATQSDYRER，用于治疗与谷氨酸兴奋性毒性相关的病理。 展开▼

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公开/公告号US10398756B2

专利类型

公开/公告日2019-09-03

原文格式PDF

申请/专利权人 MARCO FELIGIONI;ROBERT GIOVANNI NISTICO;
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申请/专利号US201715657238

发明设计人 MARCO FELIGIONI;ROBERT GIOVANNI NISTICO;
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申请日2017-07-24

分类号A61K38/16;A61K38/17;C07K14/705;A61P43;A61K38;C07K14/005;C12N15/70;

国家 US

入库时间 2022-08-21 12:14:07

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1. 用于治疗由谷氨酸兴奋性毒性引起的疾病的细胞可渗透肽系统 [P] . 中国专利： CN106414504B . 2020.12.18

2. 用于治疗由谷氨酸兴奋性毒性引起的疾病的细胞可渗透肽系统 [P] . 中国专利： CN106414504A . 2017-02-15

3. CELL-PERMEABLE PEPTIDE SYSTEM FOR TREATING DISEASES CAUSED BY GLUTAMATE EXCITOTOXICITY [P] . 欧洲知识产权局专利： EP3125917B1 . 2019-12-11

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4. Cell-permeable peptide system for treating diseases caused by glutamate excitotoxicity [P] . 美国专利： US9901618B2 . 2018-02-27

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5. CELL-PERMEABLE PEPTIDE SYSTEM FOR TREATING DISEASES CAUSED BY GLUTAMATE EXCITOTOXICITY [P] . 美国专利： US2017340701A1 . 2017-11-30

机译：细胞渗透性肽系统，用于治疗由谷氨酸兴奋性引起的疾病

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